Human SEZ6 Protein 2491

Additional Information:
accession Q53EL9|express systemHEK293|product tagC-hFc|purity> 95% as determined by Tris-Bis PAGE|backgroundSeizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the -amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.|molecular weightThe protein has a predicted MW of 124.53 kDa. Due to glycosylation, the protein migrates to 140-200 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human SEZ6 Protein 2491proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceSeizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the -amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.Protein namesSeizure protein 6 homolog (SEZ-6) (hSEZ-6)Gene namesSEZ6,SEZ6Protein familySEZ6 familyMass9606DaFunctionMay play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity).Subellular locationCell membrane ; Single-pass type I membrane protein. Note=Localized on dendrites and in the synaptic and postsynaptic fraction.Post-translational modificationGlycosylated.Target Relevance information above includes information from UniProt accession: Q53EL9The UniProt Consortium|