Name :
CFB (Human) Recombinant Protein
Biological Activity :
Human CFB full-length recombinant protein with N-terminal hexahistidine tag expressed in in HEK293EBNA1 cells.Full-Length Protein,Full-Length Proteins,Full-Length,Full Length,FullLength,Recombinant Human Protein,Recombinant Human Proteins,Human Recombinant Protein,Human Recombinant Proteins,HuPro
Tag :
Protein Accession No. :
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=629
Amino Acid Sequence :
Molecular Weight :
Storage and Stability :
Store at -80°C.Aliquot to avoid repeated freezing and thawing.
Host :
Human
Interspecies Antigen Sequence :
Preparation Method :
Mammalian cell (HEK293EBNA1) expression system
Purification :
Quality Control Testing :
NuPAGE Stained with Coomassie Blue Lane1: Reduced CFB, Lane2: Non-reduced CFB
Storage Buffer :
25 mM Tris 150 mM NaCl pH 7.5 (no preservative)
Applications :
SDS-PAGE，
Gene Name :
CFB
Gene Alias :
BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2
Gene Description :
complement factor B
Gene Summary :
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5′ end of the gene for complement component 2. [provided by RefSeq
Other Designations :
B-factor, properdin|C3 proaccelerator|C3 proactivator|C3/C5 convertase|OTTHUMP00000029283|OTTHUMP00000174690|glycine-rich beta-glycoprotein
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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