BLK Enzyme

Description:
|Introduction Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11). |Reco|E. coli-derived. Reco|> 95% by SEC-HPLC and reducing SDS-|Formulation: 0.2 um filtered solution of 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH 7.4. Shipping: The product is shipped with ice |Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. |Other BLK Enzymes: Recombinant Human BLK Enzyme