Hyperlipidemia is a prevalent condition worldwide and represents a major modifiable risk factor for cardiovascular diseases such as coronary heart disease and peripheral artery disease. Elevated serum lipid levels, particularly…
**Background** Pulmonary arterial hypertension (PAH) is a severe and often fatal orphan disease characterized by increased blood pressure in the pulmonary arteries, leading to right ventricular failure. The pathology involves…
Cancer remains a leading cause of death worldwide, with conventional chemotherapy often limited by severe side effects and multidrug resistance. To overcome these challenges, combination therapies integrating photodynamic therapy (PDT)…
Infant and pediatric mortality serve as critical indicators of population health and social well-being. In the United States, significant racial and ethnic disparities persist in both infant and child mortality…
**Background** Obesity is a complex metabolic disorder that significantly increases the risk of cardiovascular diseases, including atherosclerosis. A key factor in the development of obesity is the excessive absorption of…
Treatment of the human neuroblastoma BE(2)-M17 cell line with trans-retinoic acid (RA) induces significant morphological and functional differentiation, transforming these immature cells into a more neuron-like phenotype. After 72 hours…
**Background** The NLRP3 (nucleotide-binding oligomerization domain-like receptor protein 3) inflammasome plays a critical role in the innate immune response by triggering the maturation and release of potent pro-inflammatory cytokines. Overactivation…
Acute lymphoblastic leukemia (ALL) remains the most common childhood cancer, with significant improvements in survival rates over recent decades. However, up to one in five patients still relapse, and outcomes…
The present study investigates the differential expression of heat shock protein 70 (HSP70) in response to uphill (concentric-dominated) and downhill (eccentric-dominated) treadmill exercise across multiple tissues in rats. HSP70 is…
ATP-dependent proteases are essential cellular machines responsible for the controlled degradation of misfolded, damaged, or regulatory proteins. These complexes harness the energy from ATP binding and hydrolysis to drive substrate…