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L 1999, 151:89?4. 19. Rajkhowa M, Talbot JA, Jones PW, I-CBP112 supplier Pettersson K, Haavisto AM
L 1999, 151:89?4. 19. Rajkhowa M, Talbot JA, Jones PW, Pettersson K, Haavisto AM, Huhtaniemi I, Clayton RN: Prevalence of an immunological LH beta-subunit variant in a UK population of healthy women and women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 1995, 43:297?03. 20. Tapanainen JS, Koivunen R, Fauser BC, Taylor AE, Clayton RN, Rajkowa M, White D, Franks S, Anttila L, Pettersson KS, Huhtaniemi I: A new contributing factor to polycystic ovary syndrome: the genetic variant of luteinizing hormone. J Clin Endocrinol Metab 1999, 84:1711?715. 21. Takahashi K, Kurioka H, Ozaki T, Kanasaki H, Kohsaka M, Miyazaki K, Karino K: Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients. Hum Reprod 1998, 13:3338?344. 22. Takahashi K, Karino K, Kanasaki H, Miyazaki K: Altereted kinetics of pituitary response to gonadotropin-release hormone in woman with variant luteinizing hormone: correlation with ovulatory disorders. Horm Res 2004, 61:27?2. 23. Chen X, Zhou B, Yan J, Xu B, Tai P, Li J, Peng S, Zhang M, Xia G: Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes. J Endocrinol 2008, 197:409?19. 24. Wang C, Xu B, Zhou B, Zhang C, Yang J, Ouyang H, Ning G, Zhang M, Shen J, Xia G: Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro. J Lipid Res 2009, 50:2164?172. 25. Yang J, Fu M, Wang S, Chen X, Ning G, Xu B, Ma Y, Zhang M, Xia G: An Antisense Oligodeoxynucleotide to the LH PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25432023 Receptor Attenuates FSH-induced Oocyte Maturation in Mice. Asian-Aust J Anim Sci 2008, 21:972?79. 26. Humaidan P, Bungum M, Bungum L, Yding Andersen C: Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH: an opening study. Reprod Biomed Online 2004, 8:635?43. 27. Smyth CD, Mir?F, Whitelaw PF, Howles CM, Hillier SG: Ovarian thecal/interstitial androgen synthesis is enhanced by a follicle-stimulating hormone-stimulated paracrine mechanism. Endocrinology 1993, 133:1532?538.doi:10.1186/1477-7827-11-51 Cite this article as: Alviggi et al.: A common polymorphic allele of the LH beta-subunit gene is associated with higher exogenous FSH consumption during controlled ovarian stimulation for assisted reproductive technology. Reproductive Biology and Endocrinology 2013 11:51.Submit your next manuscript to BioMed Central and take full advantage of:?Convenient online submission ?Thorough peer review ?No space constraints or color figure charges ?Immediate publication on acceptance ?Inclusion in PubMed, CAS, Scopus and Google Scholar ?Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submit
O’Brien et al. Reproductive Biology and Endocrinology 2013, 11:71 PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28827318 http://www.rbej.com/content/11/1/RESEARCHOpen AccessAssociation between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulationTravis J O’Brien1*, Mariah M Kalmin2, Arthur F Harralson3, Adam M Clark1, Ian Gindoff1, Samuel J Simmens2, David Frankfurter4 and Paul GindoffAbstractBackground: The aim of this study was to determine the relationship between a purported luteinizing hormone/ chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ova.

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