**Background** Prostaglandin E2 (PGE2) is a key lipid mediator that exerts various physiological effects through its interaction with four G protein-coupled receptors: EP1, EP2, EP3, and EP4. Among these, the…
**Background** Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide. Among the various enzymatic targets involved in the progression of these conditions, chymase—a serine protease primarily expressed…
**Background** Plant cell walls are complex structures that provide mechanical support and protection to flowering plants. Among the various components of the secondary plant cell wall, hemicelluloses play a critical…
**Background** Cancer remains one of the most challenging diseases in modern medicine, requiring the development of potent chemotherapeutic agents to inhibit rapid tumor cell proliferation. Among the various strategies, the…
**Background** Parkinson’s disease (PD) and restless legs syndrome (RLS) are debilitating neurological disorders characterized by motor dysfunction and sleep disturbances. A primary driver of these conditions is the deficiency of…
**Background** Artificial sweeteners are widely used in the food industry as low-calorie alternatives to sugar. However, emerging research suggests that long-term consumption of these compounds may have systemic effects beyond…
**Background** Cyclic AMP-dependent protein kinase (PKA) is a critical enzyme in the signal transduction pathway that mediates the effects of various hormones and neurotransmitters. PKA consists of regulatory and catalytic…
**Background** $\alpha/\beta$-hydrolase domain containing 6 (ABHD6) is a magnesium-dependent hydrolase that primarily acts as a monoacylglycerol lipase, targeting 2-arachidonoylglycerol (2-AG), one of the primary endocannabinoids in the mammalian nervous system.…
**Background** Chronic inflammation and oxidative stress are central drivers in the pathogenesis of various debilitating conditions, including neurodegenerative diseases, hepatotoxicity, and malignancy. In particular, the overactivation of signaling pathways such…
**Background** The endocannabinoid system plays a critical role in regulating various physiological processes, including mood, appetite, pain sensation, and memory. A central component of this system is the endocannabinoid 2-arachidonoylglycerol…