Product Name :
CL075
Description:
CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.
CAS:
256922-53-9
Molecular Weight:
243.33
Formula:
C13H13N3S
Chemical Name:
2-propyl-[1,3]thiazolo[4,5-c]quinolin-4-amine
Smiles :
CCCC1=NC2=C(S1)C1=CC=CC=C1N=C2N
InChiKey:
NFYMGJSUKCDVJR-UHFFFAOYSA-N
InChi :
InChI=1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Glycyrrhizic acid Cancer
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.C18-Ceramide supplier |Product information|CAS Number: 256922-53-9|Molecular Weight: 243.33|Formula: C13H13N3S|Synonym:|3M002|Chemical Name: 2-propyl-[1,3]thiazolo[4,5-c]quinolin-4-amine|Smiles: CCCC1=NC2=C(S1)C1=CC=CC=C1N=C2N|InChiKey: NFYMGJSUKCDVJR-UHFFFAOYSA-N|InChi: InChI=1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 22 mg/mL (90.PMID:31613455 41 mM; Need ultrasonic and warming).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CL075 (2 μM; 4 h) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes. CL075 (2 μM; 48 h) induces the total IgM production and cell proliferation in rabbit splenocytes. CL075 (2 μM; 7 h) activates the rabTLR8 in 293 cells.|In Vivo:|CL075 (5 μM (0.5 mL); s.c.) activates a mild antigen-specific antibody response in rabbits.|References:|Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9.Spranger S, et, al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010 Jul 1;185(1):738-47.Maalej KM, et, al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015 Jun;97(6):1081-7.Products are for research use only. Not for human use.|
