Stock dense location only, Table S3: Associations in between presence of poultry and goat farms and antibiotic use per variety of antibiotic from negative binomial regression, for female gender only.Antibiotics 2021, 10,ten ofAuthor Contributions: Conceptualization, W.v.d.H. and C.C.H.W.; methodology, I.R., W.v.d.H., C.C.H.W. and L.A.M.S.; software, I.R. and L.O.B.; validation, I.R.; formal analysis, I.R. and L.O.B.; investigation, I.R.; information curation, I.R., L.O.B. and C.C.H.W.; writing–original draft preparation, I.R. and L.O.B.; writing–review and editing, W.v.d.H., C.C.H.W. and L.A.M.S.; visualization, I.R.; supervision, W.v.d.H., C.C.H.W. and L.A.M.S. All authors have read and agreed for the published version of the manuscript. Funding: This study was funded in the typical budget of the National Institute for Public Wellness and the Environment (RIVM). Institutional Evaluation Board Statement: Ethical review and approval have been waived for this study, as a result of use of aggregated and anonymous information. Informed Consent Statement: Not applicable. Information Availability Statement: The antibiotic prescription data that had been analyzed in the course of this study are readily available from the Drug Data Program (GIP) of your National Overall health Care Institute (in Dutch: Zorginstituut Nederland) but restrictions apply for the availability of those data, which had been employed under Pantoprazole-d3 Apoptosis license for the existing study, and so are usually not publicly accessible. Acknowledgments: We thank Ben Bom (RIVM) for performing the calculations of livestock farm presence and developing the maps. Conflicts of Interest: The authors declare no conflict of interest.Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This short article is an open access article distributed beneath the terms and conditions in the Inventive Commons Attribution (CC BY) license (licenses/by/ 4.0/).Postoperative nausea and vomiting (PONV) are typical and serious complications following an operation and are normally related with delayed recovery and extended length of hospital keep . Gynecologic laparoscopy, in certain, is correlated using a fairly larger incidence of PONV (about 80) if no Ertapenem-d4 disodium supplier prophylactic antiemetics are administered . The recognized threat elements for PONV are female sex, use of postoperative opioids like patient-controlled analgesia (PCA), volatile anesthesia, gynecologic surgery, and elevated intra-abdominal pressure throughout laparoscopy . Since the etiology of PONV is multifactorial and also the mechanism is complex, multimodal prophylaxis has been encouraged in high-risk patients . The key concept of multimodal prophylaxis is that a mixture of antiemetics of unique classes acts on distinct receptors. Habib and Gan  revealed that in individuals who did not respond to prevention using a particular class of antiemetics, administering an antiemetic of a different class was a lot more effective as a rescue agent than the agent made use of initially for prophylaxis. Many preceding studies have reported that multimodal prophylaxis was superior to single-agent prophylaxis [6,7]. AccordingJ. Clin. Med. 2021, ten, 4857. ten.3390/jcmmdpi/journal/jcmJ. Clin. Med. 2021, 10,2 ofto a brand new PONV guideline published in 2020, the indication for multimodal prophylaxis has been expanded, and it is actually now recommended to combine two or extra agents even for low-risk patients . By far the most typically made use of regimen of multim.