Re at minuteProstaglandins Leukot Essent Fatty Acids. Author manuscript; obtainable in PMC 2022 May perhaps 23.Ramsden et al.Page120 minute are primarily based on longitudinal mixed models with repeated observations controlling for the information collection round. P-values: 0.05, 0.01, 0.001.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptProstaglandins Leukot Essent Fatty Acids. Author manuscript; obtainable in PMC 2022 May perhaps 23.Ramsden et al.PageAuthor Manuscript Author Manuscript Author ManuscriptFig 4: Docosahexaenoic acid-derived oxylipins: Molecular pathways for synthesis and adjust from baseline by time and temperature.Author ManuscriptPanel A shows the molecular pathways involved in enzymatic and non-enzymatic conversion of docosahexaenoic acid (DHA) to DHA-derived oxylipins. Panel B shows individual information points for plasma concentrations of each and every of your DHA-derived oxylipin measured at baseline and following delayed processing of up to 120 minutes on wet ice or at room temperature. One particular half of the LOQ was imputed for values beneath LOQ.IGFBP-2 Protein Formulation Variations in between cold and space temperature at minute 120 minute are primarily based on longitudinal mixed models withProstaglandins Leukot Essent Fatty Acids. Author manuscript; available in PMC 2022 Could 23.Ramsden et al.Pagerepeated observations controlling for the data collection round. P-values: 0.05, 0.01, 0.001.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptProstaglandins Leukot Essent Fatty Acids. Author manuscript; obtainable in PMC 2022 May well 23.Ramsden et al.PageAuthor Manuscript Author Manuscript Author ManuscriptFig 5: Linoleic acid-derived oxylipins: Molecular pathways for synthesis and adjust from baseline by time and temperature.Author ManuscriptPanel A shows the molecular pathways involved in enzymatic and non-enzymatic conversion of linoleic acid (LA) to LA-derived oxylipins. Panel B shows individual information points for plasma concentrations of every single of your DHA-derived oxylipin measured at baseline and following delayed processing of up to 120 minutes on wet ice or at room temperature. A single half of the LOQ was imputed for values below LOQ. Differences amongst cold and room temperature at minute 120 minute are based on longitudinal mixed models withProstaglandins Leukot Essent Fatty Acids. Author manuscript; available in PMC 2022 May 23.Ramsden et al.Pagerepeated observations controlling for the data collection round.TRAIL/TNFSF10, Rhesus Macaque P-values: 0.PMID:23903683 05, 0.01, 0.001.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptProstaglandins Leukot Essent Fatty Acids. Author manuscript; out there in PMC 2022 Could 23.Ramsden et al.PageTable 1.Model-predicted oxylipin estimates following 120 minutes of exposure to room temperature or wet ice (ng/ml)Wet ice Estimate (95 CI) Space temperature Estimate (95 CI) Difference (Room-Wet Ice) Estimate (95 CI) p-valueAuthor Manuscript Author Manuscript Author Manuscript Author ManuscriptAA5-HETE 12-HETE 15-HETE TXB2 0.22 (0.18, 0.26) 0.25 (0.07, 0.43) 0.41 (0.35, 0.48) 0.05 (0.03, 0.08) 0.21 (0.16, 0.25) 0.62 (0.43, 0.80) 0.36 (0.30, 0.43) 0.ten (0.07, 0.12) -0.01 (-0.07, 0.05) 0.37 (0.11, 0.62) -0.05 (-0.14, 0.04) 0.05 (0.01, 0.08) 0.69 0.005 0.246 0.DHA4-HDHA 10-HDHA 14-HDHA 17-HDHA 19,20-EpDPA 0.13 (0.12, 0.15) 0.05 (0.04, 0.06) 0.07 (0.02, 0.12) 0.34 (0.27, 0.42) 0.07 (0.06, 0.07) 0.11 (0.ten, 0.13) 0.05 (0.04, 0.05) 0.20 (0.14, 0.25) 0.33 (0.26, 0.40) 0.07 (0.06, 0.08) -0.02 (-0.04, 0.00) -0.00 (-0.01, 0.01) 0.13 (0.06, 0.20) -0.01 (-0.12, 0.09) 0.00 (-0.0.
