) Re-ligation of G-segment. (7) Opening of C-gate and passage of T-segment and release of 2ADP. (eight) Enzyme resetting and representation of duplex DNA with n linking quantity. Figure S2. Three sequence alignment presented in yeast (ScTopo II) and human topo II isoforms A: Differences in TOPRIM domain (Cys443 eu557 for ScTopo II; Cys455 lu572 for HsTopo II and Cys476 lu593 for HsTopo II); B: Region responsible for interaction with DNA (Lys965 sn974 for ScTopo II; Lys990 er999 for HsTopo II and Lys1011 er1020 for HsTopo II); C: Conserved sequences represented in K-loop region of both yeast and human isoforms. Figure S3: Numerous sequence alignment of 3 diverse fungal species Saccharomyces cerevisiae, Candida albicans and Candida glabrata with human topo II isoforms is depicted. Uniprot ID talked about inside the left. The red rectangular bars indicate significant consensus sequences like K-loop (33338 residues), metal bound region (D from 52628 residues), intercalator region (I at residue 833) and catalytic tyrosine (Y at 782 residue) with respect to S. cerevisiae. The differences are marked in blue rectangular bars. Animated graphical representation of yeast topoisomerase II presenting several sites of this enzyme can also be supplied. The film was prepared by Molywood [105]. Author Contributions: Conceptualization, I.G. and K.K.; writing–original draft preparation, K.K.; writing–review and editing, I.G. and K.K.; supervision, I.G. All authors have study and agreed for the published version with the manuscript.AUDA Metabolic Enzyme/Protease Funding: This study received no external funding. Institutional Overview Board Statement: Not applicable. Informed Consent Statement: Not applicable. Information Availability Statement: Not applicable. Acknowledgments: The authors would prefer to thank Subrahmanyam Sappati for his assistance with bioinformatics analysis. Conflicts of Interest: The authors declare no conflict of interest.
Received: 30 September 2021 Revised: 7 January 2022 Accepted: 10 January 2022 DOI: 10.1111/aogs.||ORIGINAL Investigation ARTICLEWeight modify through the initial week of life and a new method for retrospective prediction of birthweight among exclusively breastfed newbornsGeorge Mtove1 | Omari Abdul1| Fanny Kullberg2| Samwel Gesase1| Thomas Scheike3| Frederik M kj Andersen3| Mwayiwawo Madanitsa4| Feiko O.CNQX Biological Activity ter Kuile5| Michael Alifrangis2| John P.PMID:25804060 A. Lusingu1,2| Daniel T. R. Minja1| Christentze SchmiegelowNational Institute for Health-related Research, Tanga Health-related Analysis Centre, Tanga, Tanzania Centre for Healthcare Parasitology, Division of Immunology and Microbiology, University of Copenhagen, Copenhagen and Division of Infectious Illnesses, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark Malawi University of Science and Technology, Thyolo, Malawi5 Division of Clinical Sciences, Liverpool College of Tropical Medicine, Liverpool, UK four 3 2AbstractIntroduction: Identification of low birthweight and smaller for gestational age is pivotal in clinical management and quite a few investigation research, but in low-income countries, birthweight is frequently unavailable within 24 h of birth. Newborn weights measured inside days following birth and information in the growth patterns in the first week of life can assist estimate the weight at birth retrospectively. This study aimed to produce sex-specific prediction maps and weight reference charts for the retrospective estimation of birthweight.
