Product Name :
Rabbit anti-TRIM72 Polyclonal Antibody(C-term)
Synonym :
Tripartite motif-containing protein 72; Mitsugumin-53; Mg53; TRIM72; MG53
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.
Predicted Reactivity:
Applications :
WB~~1:2000IHC-P~~1:10~50
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cell Biology;Signal Transduction
Background :
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
UniProt :
Q6ZMU5
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Tripartite motif-containing protein 72; Mitsugumin-53; Mg53; TRIM72; MG53 |Host Rabbit |Specificity This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72. |Species Reactivity Human, Mouse, Rat |Applications WB~~1:2000IHC-P~~1:10~50 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cell Biology;Signal Transduction |Target |Background Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). |Cellular localization Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. |UniProt Q6ZMU5 |References |References Park, E.Y., et al. Proteins 78(3):790-795(2010)Han, S., et al. Hum. Mol. Genet. 18(6):1171-1180(2009)Martin, J., et al. Nature 432(7020):988-994(2004) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-TRIM72 Polyclonal Antibody(C-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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